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| Molecular Profile | FGFR2 C382R |
| Therapy | Pemigatinib |
| Indication/Tumor Type | intrahepatic cholangiocarcinoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FGFR2 C382R | intrahepatic cholangiocarcinoma | predicted - sensitive | Pemigatinib | Case Reports/Case Series | Actionable | In a clinical case study, Pemazyre (pemigatinib) treatment resulted in complete metabolic remission in a patient with metastatic intrahepatic cholangiocarcinoma harboring FGFR2 C382R (PMID: 36188486). | 36188486 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (36188486) | A new promising oncogenic target (p.C382R) for treatment with pemigatinib in patients with cholangiocarcinoma. | Full reference... |