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| Molecular Profile | FLT3 positive |
| Therapy | CLN-049 |
| Indication/Tumor Type | acute myeloid leukemia |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FLT3 positive | acute myeloid leukemia | predicted - sensitive | CLN-049 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, CLN-049 decreased growth and increased survival in a cell line xenograft model of FLT3-positive acute myeloid leukemia (Cancer Res 2022;82(12_Suppl):Abstract nr 2078). | detail... |
| PubMed Id | Reference Title | Details |
|---|---|---|
| CLN-049 is a bispecific T cell engaging IgG-like antibody targeting FLT3 on AML cells | Full reference... |