Therapy Detail
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| Therapy Name | CLN-049 |
| Synonyms | |
| Therapy Description |
CLN-049 is a bispecific antibody that targets FLT3 and CD3, potentially inducing activation of CD4- and CD8-positive T cells and inhibiting tumor growth (Cancer Res 2022;82(12_Suppl):Abstract nr 2078). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| CLN-049 | CLN049|CLN 049 | CD3 Antibody 103 FLT3 Antibody 5 | CLN-049 is a bispecific antibody that targets FLT3 and CD3, potentially inducing activation of CD4- and CD8-positive T cells and inhibiting tumor growth (Cancer Res 2022;82(12_Suppl):Abstract nr 2078). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FLT3 positive | acute myeloid leukemia | predicted - sensitive | CLN-049 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, CLN-049 decreased growth and increased survival in a cell line xenograft model of FLT3-positive acute myeloid leukemia (Cancer Res 2022;82(12_Suppl):Abstract nr 2078). | detail... |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05143996 | Phase I | CLN-049 | CLN-049 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML) | Recruiting | USA | 0 |
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