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Molecular Profile | KIT V560D KIT D820A |
Therapy | Imatinib |
Indication/Tumor Type | gastrointestinal stromal tumor |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT V560D KIT D820A | gastrointestinal stromal tumor | resistant | Imatinib | Preclinical | Actionable | In a preclinical study, a gastrointestinal stromal tumor cell line harboring KIT V560D and KIT D820A demonstrated resistance to Gleevec (imatinib) in culture (PMID: 16954519). | 16954519 |
KIT V560D KIT D820A | gastrointestinal stromal tumor | resistant | Imatinib | Case Reports/Case Series | Actionable | In a clinical study, KIT D820A was identified as a secondary mutation in a patient with gastrointestinal stromal tumor harboring a primary KIT V560D mutation, who developed resistance to Gleevec (imatinib mesylate) (PMID: 16954519). | 16954519 |
PubMed Id | Reference Title | Details |
---|---|---|
(16954519) | Molecular correlates of imatinib resistance in gastrointestinal stromal tumors. | Full reference... |
(16954519) | Molecular correlates of imatinib resistance in gastrointestinal stromal tumors. | Full reference... |