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| Molecular Profile | EML4 - ALK |
| Therapy | Crizotinib |
| Indication/Tumor Type | large cell neuroendocrine carcinoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| EML4 - ALK | large cell neuroendocrine carcinoma | predicted - sensitive | Crizotinib | Case Reports/Case Series | Actionable | In a clinical case study, Xalkori (crizotinib) treatment resulted in stable disease with early progression after 3 months in a patient with metastatic large cell neuroendocrine lung carcinoma harboring EML4-ALK (e20:e20) (PMID: 36207130). | 36207130 |
| EML4 - ALK | large cell neuroendocrine carcinoma | predicted - sensitive | Crizotinib | Case Reports/Case Series | Actionable | In a clinical case study, Xalkori (crizotinib) treatment resulted in regression of all previously identified lesions in a patient with large cell neuroendocrine carcinoma harboring EML4-ALK (PMID: 30154667). | 30154667 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (36207130) | Lorlatinib and compound mutations in ALK+ large-cell neuroendocrine lung carcinoma: a case report. | Full reference... |
| (30154667) | ALK-rearrangement neuroendocrine carcinoma of the lung: a comprehensive study of a rare case series and review of literature. | Full reference... |