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| Molecular Profile | KIT V560D KIT D820A |
| Therapy | Sunitinib |
| Indication/Tumor Type | gastrointestinal stromal tumor |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT V560D KIT D820A | gastrointestinal stromal tumor | resistant | Sunitinib | Preclinical | Actionable | In a preclinical study, a gastrointestinal stromal tumor cell line harboring KIT V560D and KIT D820A demonstrated resistance to Sutent (sunitinib) in culture (PMID: 18955458). | 18955458 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (18955458) | Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumor. | Full reference... |