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Molecular Profile | KIT V560D KIT D820A |
Therapy | Imatinib + Infigratinib |
Indication/Tumor Type | gastrointestinal stromal tumor |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT V560D KIT D820A | gastrointestinal stromal tumor | predicted - sensitive | Imatinib + Infigratinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, combination treatment with Gleevec (imatinib) and Truseltiq (infigratinib) treatment resulted in tumor shrinkage in a gastrointestinal stromal tumor cell line xenograft model harboring KIT V560D and KIT D820A (PMID: 35625872). | 35625872 |
PubMed Id | Reference Title | Details |
---|---|---|
(35625872) | In Vivo Evaluation of Fibroblast Growth Factor Receptor Inhibition in Mouse Xenograft Models of Gastrointestinal Stromal Tumor. | Full reference... |