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Molecular Profile | KIT A502_Y503dup |
Therapy | Binimetinib + Dovitinib |
Indication/Tumor Type | gastrointestinal stromal tumor |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT A502_Y503dup | gastrointestinal stromal tumor | predicted - sensitive | Binimetinib + Dovitinib | Preclinical - Pdx | Actionable | In preclinical study, combination treatment with Mektovi (binimetinib) and Dovitinib (TKI258) resulted in tumor shrinkage in a patient-derived xenograft (PDX) model of gastrointestinal stromal tumor harboring KIT A502_Y503dup (PMID: 35625872). | 35625872 |
PubMed Id | Reference Title | Details |
---|---|---|
(35625872) | In Vivo Evaluation of Fibroblast Growth Factor Receptor Inhibition in Mouse Xenograft Models of Gastrointestinal Stromal Tumor. | Full reference... |