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Molecular Profile KIT A502_Y503dup
Therapy Binimetinib + Dovitinib
Indication/Tumor Type gastrointestinal stromal tumor
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT A502_Y503dup gastrointestinal stromal tumor predicted - sensitive Binimetinib + Dovitinib Preclinical - Pdx Actionable In preclinical study, combination treatment with Mektovi (binimetinib) and Dovitinib (TKI258) resulted in tumor shrinkage in a patient-derived xenograft (PDX) model of gastrointestinal stromal tumor harboring KIT A502_Y503dup (PMID: 35625872). 35625872
PubMed Id Reference Title Details
(35625872) In Vivo Evaluation of Fibroblast Growth Factor Receptor Inhibition in Mouse Xenograft Models of Gastrointestinal Stromal Tumor. Full reference...