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| Molecular Profile | EML4 - ALK ALK C1156Y ALK I1171N |
| Therapy | Gilteritinib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| EML4 - ALK ALK C1156Y ALK I1171N | Advanced Solid Tumor | sensitive | Gilteritinib | Preclinical - Cell culture | Actionable | In a preclinical study, Xospata (gilteritinib) treatment inhibited Alk phosphorylation and viability of transformed cells expressing EML4-ALK with ALK I1171N and C1156Y in culture (PMID: 36201110). | 36201110 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (36201110) | Prediction of Resistance Mutations Against Upcoming Anaplastic Lymphoma Kinase Inhibitors. | Full reference... |