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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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VHL V166F | leukemia | resistant | ARV-771 | Preclinical - Cell culture | Actionable | In a preclinical study, a leukemia cell line demonstrated resistance to ARV-771 and was found to have acquired VHL V166F in culture (PMID: 36329119). | 36329119 |
PubMed Id | Reference Title | Details |
---|---|---|
(36329119) | Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders. | Full reference... |