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Therapy Name ARV-771
Synonyms
Therapy Description

ARV-771 is a bifunctional molecule that targets BET proteins for proteolytic degradation, resulting in reduced target gene expression and potentially leading to increased apoptosis and reduced tumor growth (PMID: 31217338, PMID: 27274052, PMID: 30575820).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ARV-771 ARV 771|ARV771 BET Inhibitor (Pan) 32 ARV-771 is a bifunctional molecule that targets BET proteins for proteolytic degradation, resulting in reduced target gene expression and potentially leading to increased apoptosis and reduced tumor growth (PMID: 31217338, PMID: 27274052, PMID: 30575820).

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
VHL H110L colon carcinoma sensitive ARV-771 Preclinical - Cell culture Actionable In a preclinical study, ARV-771 inhibited viability in a colon carcinoma cell line expressing VHL H110L in culture (PMID: 36329119). 36329119
VHL Y112C leukemia resistant ARV-771 Preclinical - Cell culture Actionable In a preclinical study, a leukemia cell line demonstrated resistance to ARV-771 and was found to have acquired VHL Y112C in culture (PMID: 36329119). 36329119
VHL S139fs leukemia resistant ARV-771 Preclinical - Cell culture Actionable In a preclinical study, a leukemia cell line demonstrated resistance to ARV-771 and was found to have acquired VHL S139fs in culture (PMID: 36329119). 36329119
VHL Y112C colon carcinoma resistant ARV-771 Preclinical - Cell culture Actionable In a preclinical study, a colon carcinoma cell line expressing VHL Y112C was resistant to ARV-771 in culture (PMID: 36329119). 36329119
VHL W117* leukemia resistant ARV-771 Preclinical - Cell culture Actionable In a preclinical study, a leukemia cell line demonstrated resistance to ARV-771 and was found to have acquired VHL W117* in culture (PMID: 36329119). 36329119
VHL S111R leukemia resistant ARV-771 Preclinical - Cell culture Actionable In a preclinical study, a leukemia cell line demonstrated resistance to ARV-771 and was found to have acquired VHL S111R in culture (PMID: 36329119). 36329119
VHL V166F leukemia resistant ARV-771 Preclinical - Cell culture Actionable In a preclinical study, a leukemia cell line demonstrated resistance to ARV-771 and was found to have acquired VHL V166F in culture (PMID: 36329119). 36329119

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries


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