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Molecular Profile IDH1 R132H IDH1 D279N
Therapy LY3410738
Indication/Tumor Type acute myeloid leukemia
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
IDH1 R132H IDH1 D279N acute myeloid leukemia sensitive LY3410738 Preclinical - Cell culture Actionable In a preclinical study, LY3410738 inhibited (R)-2-hydroxyglutarate (R-2HG) production and cytokine-independent growth in an acute myeloid leukemia cell line expressing IDH1 R132H and D279N in culture (PMID: 36056177). 36056177
PubMed Id Reference Title Details
(36056177) Secondary IDH1 resistance mutations and oncogenic IDH2 mutations cause acquired resistance to ivosidenib in cholangiocarcinoma. Full reference...