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| Molecular Profile | CSF1R over exp |
| Therapy | Pexidartinib |
| Indication/Tumor Type | tenosynovial giant cell tumor |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| CSF1R over exp | tenosynovial giant cell tumor | sensitive | Pexidartinib | Phase I | Actionable | In a Phase I trial, PLX3397 reduced tenosynovial giant cell tumor volume in patients with overexpression of Csf1r (PMID: 26222558). | 26222558 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26222558) | Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor. | Full reference... |