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| Molecular Profile | FLT3 exon 14 ins FLT3 D835Y |
| Therapy | Tuspetinib |
| Indication/Tumor Type | acute myeloid leukemia |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FLT3 exon 14 ins FLT3 D835Y | acute myeloid leukemia | predicted - sensitive | Tuspetinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Tuspetinib (HM43239) treatment resulted in tumor regression in a cell line xenograft model of acute myeloid leukemia expressing a FLT3 ITD mutation and FLT3 D835Y (Cancer Res 2021;81(13_Suppl):Abstract nr 1257). | detail... |
| PubMed Id | Reference Title | Details |
|---|---|---|
| Abstract 1257: HM43239, a novel FLT3 inhibitor, has the potential to inhibit mutations resistant to FLT3 inhibitors | Full reference... |