Therapy Detail
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| Therapy Name | Tuspetinib |
| Synonyms | |
| Therapy Description |
Tuspetinib (HM43239) inhibits both wild-type and mutant FLT3, resulting in decreased activation of downstream signaling, and potentially leading to increased apoptosis and decreased proliferation of tumor cells (Cancer Res 2019;79(13 Suppl):Abstract nr 1293). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Tuspetinib | HM-43239|HM 43239|HM43239 | FLT3 Inhibitor 69 | Tuspetinib (HM43239) inhibits both wild-type and mutant FLT3, resulting in decreased activation of downstream signaling, and potentially leading to increased apoptosis and decreased proliferation of tumor cells (Cancer Res 2019;79(13 Suppl):Abstract nr 1293). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FLT3 exon 14 ins FLT3 D835Y | hematologic cancer | predicted - sensitive | Tuspetinib | Preclinical | Actionable | In a preclinical study, Tuspetinib (HM43239) treatment inhibited transformed cells expressing FLT3 ITD and D835Y in cell culture (Cancer Res 2019;79(13 Suppl):Abstract nr 1293). | detail... |
| FLT3 exon 14 ins FLT3 F691L | hematologic cancer | predicted - sensitive | Tuspetinib | Preclinical | Actionable | In a preclinical study, Tuspetinib (HM43239) treatment inhibited transformed cells expressing FLT3 ITD and F691L in cell culture (Cancer Res 2019;79(13 Suppl):Abstract nr 1293). | detail... |
| FLT3 exon 14 ins FLT3 D835Y | acute myeloid leukemia | predicted - sensitive | Tuspetinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Tuspetinib (HM43239) treatment resulted in tumor regression in a cell line xenograft model of acute myeloid leukemia expressing a FLT3 ITD mutation and FLT3 D835Y (Cancer Res 2021;81(13_Suppl):Abstract nr 1257). | detail... |
| FLT3 exon 14 ins FLT3 F691L | acute myeloid leukemia | predicted - sensitive | Tuspetinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Tuspetinib (HM43239) treatment resulted in tumor regression in a cell line xenograft model of acute myeloid leukemia expressing a FLT3 ITD mutation and FLT3 F691L (Cancer Res 2021;81(13_Suppl):Abstract nr 1257). | detail... |
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03850574 | Phase Ib/II | Tuspetinib + Venetoclax Tuspetinib | Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Tuspetinib (HM43239) in Patients With Relapsed or Refractory Acute Myeloid Leukemia (APTIVATE) | Recruiting | USA | NZL | ESP | DEU | AUS | 1 |
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