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Molecular Profile BRAF V600E
Therapy Navitoclax + Ulixertinib
Indication/Tumor Type pleomorphic xanthoastrocytoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E pleomorphic xanthoastrocytoma sensitive Navitoclax + Ulixertinib Preclinical - Cell line xenograft Actionable In a preclinical study, the combination of Ulixertinib (BVD-523) and Navitoclax (ABT-263) synergistically induced apoptosis in a pleomorphic xanthoastrocytoma cell line harboring BRAF V600E in culture, and improved the partial response rate compared to either drug alone in a zebrafish xenograft model (PMID: 35882450). 35882450
PubMed Id Reference Title Details
(35882450) The first-in-class ERK inhibitor ulixertinib shows promising activity in mitogen-activated protein kinase (MAPK)-driven pediatric low-grade glioma models. Full reference...