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Molecular Profile | BRAF V600E |
Therapy | Navitoclax + Ulixertinib |
Indication/Tumor Type | pleomorphic xanthoastrocytoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E | pleomorphic xanthoastrocytoma | sensitive | Navitoclax + Ulixertinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, the combination of Ulixertinib (BVD-523) and Navitoclax (ABT-263) synergistically induced apoptosis in a pleomorphic xanthoastrocytoma cell line harboring BRAF V600E in culture, and improved the partial response rate compared to either drug alone in a zebrafish xenograft model (PMID: 35882450). | 35882450 |
PubMed Id | Reference Title | Details |
---|---|---|
(35882450) | The first-in-class ERK inhibitor ulixertinib shows promising activity in mitogen-activated protein kinase (MAPK)-driven pediatric low-grade glioma models. | Full reference... |