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ID | DOID:4852 |
Name | pleomorphic xanthoastrocytoma |
Definition | A low grade glioma that is characterized by pleomorphic and lipidized cells expressing GFAP often surrounded by a reticulin network and eosinophilic granular bodies. |
Source | DiseaseOntology.org |
Alt Ids | |
Path | disease disease of cellular proliferation benign neoplasm cell type benign neoplasm low grade glioma pleomorphic xanthoastrocytoma |
Molecular Profile | Therapy | Indication/Tumor Type | Response Type | Profile Response Detail |
---|---|---|---|---|
BRAF V600E | Dabrafenib + Trametinib | pleomorphic xanthoastrocytoma | sensitive | detail... |
BRAF V600E | Vemurafenib | pleomorphic xanthoastrocytoma | predicted - sensitive | detail... |
BRAF V600E | Cobimetinib + Vemurafenib | pleomorphic xanthoastrocytoma | sensitive | detail... |
BRAF V600E | Trametinib | pleomorphic xanthoastrocytoma | predicted - sensitive | detail... |
BRAF V600E | Binimetinib + Ulixertinib | pleomorphic xanthoastrocytoma | sensitive | detail... |
BRAF V600E | Selumetinib + Ulixertinib | pleomorphic xanthoastrocytoma | predicted - sensitive | detail... |
BRAF V600E | Ulixertinib + Vinblastine | pleomorphic xanthoastrocytoma | sensitive | detail... |
BRAF V600E | Trametinib + Ulixertinib | pleomorphic xanthoastrocytoma | predicted - sensitive | detail... |
BRAF V600E | Navitoclax + Ulixertinib | pleomorphic xanthoastrocytoma | sensitive | detail... |
BRAF V600E | Ulixertinib | pleomorphic xanthoastrocytoma | sensitive | detail... |
BRAF V600E | PF-07799933 | pleomorphic xanthoastrocytoma | predicted - sensitive | detail... |
BRAF V600E | Dabrafenib | pleomorphic xanthoastrocytoma | predicted - sensitive | detail... |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT01837862 | Phase Ib/II | Carboplatin + Mebendazole + Temozolomide + Vincristine Sulfate Bevacizumab + Irinotecan + Mebendazole | A Phase I/II Study of Mebendazole for the Treatment of Pediatric Gliomas | Completed | USA | 0 |
NCT01999270 | Phase I | Bevacizumab + Irinotecan | Evaluation of FDOPA-PET/MRI in Pediatric Patients With CNS Tumors | Completed | USA | 0 |
NCT03919071 | Phase II | Dabrafenib + Trametinib | Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma | Recruiting | USA | 1 |
NCT03973918 | Phase II | Binimetinib + Encorafenib | Study of Binimetinib With Encorafenib in Adults With Recurrent BRAF V600-Mutated HGG (BRAF) | Terminated | USA | 0 |
NCT03975829 | FDA approved | Dabrafenib + Trametinib | Pediatric Long-Term Follow-up and Rollover Study | Active, not recruiting | USA | SWE | NLD | ITA | ISR | GBR | FRA | FIN | ESP | DNK | DEU | CZE | CAN | BRA | BEL | AUS | ARG | 2 |
NCT04254419 | Phase I | Intra-tumoral Injection of Natural Killer Cells in High-Grade Gliomas | Not yet recruiting | USA | 0 | |
NCT04541082 | Phase I | ONC206 | Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms | Recruiting | USA | 0 |
NCT04923126 | Phase Ib/II | PD-0325901 | SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma | Recruiting | USA | 0 |
NCT05180825 | Phase II | Vinblastine Trametinib | Pediatric Low Grade Glioma - MEKinhibitor TRIal vs Chemotherapy (PLGG - MEKTRIC) | Recruiting | FRA | 0 |