pleomorphic xanthoastrocytoma
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ID DOID:4852
Name pleomorphic xanthoastrocytoma
Definition A low grade glioma that is characterized by pleomorphic and lipidized cells expressing GFAP often surrounded by a reticulin network and eosinophilic granular bodies.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation benign neoplasm cell type benign neoplasm low grade glioma pleomorphic xanthoastrocytoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
BRAF V600E Dabrafenib + Trametinib pleomorphic xanthoastrocytoma sensitive detail...
BRAF V600E Vemurafenib pleomorphic xanthoastrocytoma predicted - sensitive detail...
BRAF V600E Cobimetinib + Vemurafenib pleomorphic xanthoastrocytoma sensitive detail...
BRAF V600E Trametinib pleomorphic xanthoastrocytoma predicted - sensitive detail...
BRAF V600E Binimetinib + Ulixertinib pleomorphic xanthoastrocytoma sensitive detail...
BRAF V600E Selumetinib + Ulixertinib pleomorphic xanthoastrocytoma predicted - sensitive detail...
BRAF V600E Ulixertinib + Vinblastine pleomorphic xanthoastrocytoma sensitive detail...
BRAF V600E Trametinib + Ulixertinib pleomorphic xanthoastrocytoma predicted - sensitive detail...
BRAF V600E Navitoclax + Ulixertinib pleomorphic xanthoastrocytoma sensitive detail...
BRAF V600E Ulixertinib pleomorphic xanthoastrocytoma sensitive detail...
BRAF V600E PF-07799933 pleomorphic xanthoastrocytoma predicted - sensitive detail...
BRAF V600E Dabrafenib pleomorphic xanthoastrocytoma predicted - sensitive detail...
BRAF V600X Tovorafenib pleomorphic xanthoastrocytoma sensitive detail...
BRAF rearrange Tovorafenib pleomorphic xanthoastrocytoma sensitive detail...
BRAF fusion Tovorafenib pleomorphic xanthoastrocytoma sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01837862 Phase Ib/II Carboplatin + Mebendazole + Temozolomide + Vincristine Sulfate Bevacizumab + Irinotecan + Mebendazole A Phase I/II Study of Mebendazole for the Treatment of Pediatric Gliomas Completed USA 0
NCT01999270 Phase I Bevacizumab + Irinotecan Evaluation of FDOPA-PET/MRI in Pediatric Patients With CNS Tumors Completed USA 0
NCT03919071 Phase II Dabrafenib + Trametinib Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma Active, not recruiting USA 1
NCT03973918 Phase II Binimetinib + Encorafenib Study of Binimetinib With Encorafenib in Adults With Recurrent BRAF V600-Mutated HGG (BRAF) Terminated USA 0
NCT03975829 FDA approved Dabrafenib + Trametinib Pediatric Long-Term Follow-up and Rollover Study Active, not recruiting USA | SWE | NLD | ITA | ISR | GBR | FRA | FIN | ESP | DNK | DEU | CZE | CAN | BRA | BEL | AUS | ARG 2
NCT04541082 Phase I ONC206 Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms Recruiting USA 0
NCT04923126 Phase Ib/II Mirdametinib SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma Recruiting USA 0
NCT05180825 Phase II Vinblastine Trametinib Pediatric Low Grade Glioma - MEKinhibitor TRIal vs Chemotherapy (PLGG - MEKTRIC) Recruiting FRA 0