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| Molecular Profile | JAK2 V617F |
| Therapy | Crizotinib |
| Indication/Tumor Type | hematologic cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| JAK2 V617F | hematologic cancer | sensitive | Crizotinib | Preclinical - Cell culture | Actionable | In a preclinical study, Xalkori (crizotinib) inhibited cell proliferation and phosphorylation of Stat3, Jak2, and Ron in hematopoietic cell lines harboring JAK2 V617F in culture (PMID: 36537918). | 36537918 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (36537918) | Crizotinib Has Preclinical Efficacy in Philadelphia-Negative Myeloproliferative Neoplasms. | Full reference... |