Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Molecular Profile | ATM Q628Pfs*7 ATM I1581Nfs*5 ATM A2843V |
Therapy | RP-3500 |
Indication/Tumor Type | colon adenocarcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ATM Q628Pfs*7 ATM I1581Nfs*5 ATM A2843V | colon adenocarcinoma | sensitive | RP-3500 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, RP-3500 inhibited viability in a colon adenocarcinoma cell line harboring ATM Q628Pfs*7, ATM I1581Nfs*5, and ATM A2843V in culture, and inhibited tumor growth in a cell line xenograft model (PMID: 34911817). | 34911817 |
PubMed Id | Reference Title | Details |
---|---|---|
(34911817) | RP-3500: A Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors. | Full reference... |