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Molecular Profile ATM Q628Pfs*7 ATM I1581Nfs*5 ATM A2843V
Therapy RP-3500
Indication/Tumor Type colon adenocarcinoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM Q628Pfs*7 ATM I1581Nfs*5 ATM A2843V colon adenocarcinoma sensitive RP-3500 Preclinical - Cell line xenograft Actionable In a preclinical study, RP-3500 inhibited viability in a colon adenocarcinoma cell line harboring ATM Q628Pfs*7, ATM I1581Nfs*5, and ATM A2843V in culture, and inhibited tumor growth in a cell line xenograft model (PMID: 34911817). 34911817
PubMed Id Reference Title Details
(34911817) RP-3500: A Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors. Full reference...