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| Molecular Profile | BRAF V600E MAP2K1 G128D |
| Therapy | Dabrafenib |
| Indication/Tumor Type | melanoma |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF V600E MAP2K1 G128D | melanoma | resistant | Dabrafenib | Preclinical - Cell culture | Actionable | In a preclinical study, a melanoma cell line harboring BRAF V600E and expressing MAP2K1 G128D was resistant to Tafinlar (dabrafenib) in culture (PMID: 36442478). | 36442478 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (36442478) | High-Throughput Functional Evaluation of MAP2K1 Variants in Cancer. | Full reference... |