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Molecular Profile KMT2A rearrange
Therapy Revumenib
Indication/Tumor Type acute myeloid leukemia
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KMT2A rearrange acute myeloid leukemia sensitive Revumenib Guideline Actionable Revuforj (revumenib) is included in guidelines for patients with relapsed or refractory acute myeloid leukemia harboring a KMT2A rearrangement (NCCN.org). detail...
KMT2A rearrange acute myeloid leukemia sensitive Revumenib Case Reports/Case Series Actionable In a Phase I trial (AUGMENT-101), Revuforj (revumenib) treatment resulted in an initial response with morphological leukemia-free states in 2 patients with acute myeloid leukemia harboring KMT2A rearrangements (PMID: 36922589; NCT04065399). 36922589
PubMed Id Reference Title Details
NCCN.org Full reference...
(36922589) MEN1 mutations mediate clinical resistance to menin inhibition. Full reference...