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Molecular Profile | FGFR2 over exp |
Therapy | Bemarituzumab + Fluorouracil + Leucovorin + Oxaliplatin |
Indication/Tumor Type | gastric adenocarcinoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR2 over exp | gastric adenocarcinoma | predicted - sensitive | Bemarituzumab + Fluorouracil + Leucovorin + Oxaliplatin | Phase II | Actionable | In a Phase II trial (FIGHT), the addition of Bemarituzumab (FPA144) to mFOLFOX6 treatment resulted in improved progression-free survival (9.5 months vs 7.4 months, HR=0.68, p=0.073) that did not reach statistical significance, and improved overall survival (not reached vs 12.9 months, HR=0.58, p=0.027) compared to mFOLFOX6 plus placebo in gastric or gastroesophageal junction adenocarcinoma patients with overexpression of FGFR2b (PMID: 36244398; NCT03694522). | 36244398 |
PubMed Id | Reference Title | Details |
---|---|---|
(36244398) | Bemarituzumab in patients with FGFR2b-selected gastric or gastro-oesophageal junction adenocarcinoma (FIGHT): a randomised, double-blind, placebo-controlled, phase 2 study. | Full reference... |