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Molecular Profile | FLT3 exon 14 ins FLT3 N676D |
Therapy | PHI-101 |
Indication/Tumor Type | hematologic cancer |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 exon 14 ins FLT3 N676D | hematologic cancer | predicted - sensitive | PHI-101 | Preclinical - Biochemical | Actionable | In a preclinical study, PHI-101 demonstrated activity against FLT3 N676D in the context of a FLT3-ITD mutation in culture (Cancer Res 2020;80(16 Suppl):Abstract nr 4226). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
Abstract 4226: PHI-101, a next generation FLT3 inhibitor for acute myeloid leukemia | Full reference... |