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Molecular Profile | PIK3CA E542Q PIK3CA E674Q |
Therapy | Alpelisib + Nintedanib |
Indication/Tumor Type | urinary bladder cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA E542Q PIK3CA E674Q | urinary bladder cancer | sensitive | Alpelisib + Nintedanib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, combination treatment with Ofev (nintedanib) and Piqray (alpelisib) led to synergistic inhibition of growth in bladder cancer cell lines harboring PIK3CA E542Q and PIK3CA E674Q in culture, and led to inhibition of tumor growth in a cell line xenograft model (PMID: 36805958). | 36805958 |
PubMed Id | Reference Title | Details |
---|---|---|
(36805958) | Tumor and Stromal Cell Targeting with Nintedanib and Alpelisib Overcomes Intrinsic Bladder Cancer Resistance. | Full reference... |