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Molecular Profile | ALK G1202R ALK D1276_R1279delinsE |
Therapy | Crizotinib |
Indication/Tumor Type | neuroblastoma |
Response Type | predicted - resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ALK G1202R ALK D1276_R1279delinsE | neuroblastoma | predicted - resistant | Crizotinib | Case Reports/Case Series | Actionable | In a clinical case study, a neuroblastoma patient harboring ALK D1276_R1279delinsE developed progressive disease on treatment with Xalkori (crizotinib) and was found to have acquired ALK G1202R via circulating tumor DNA (PMID: 37147298). | 37147298 |
PubMed Id | Reference Title | Details |
---|---|---|
(37147298) | Circulating tumor DNA reveals mechanisms of lorlatinib resistance in patients with relapsed/refractory ALK-driven neuroblastoma. | Full reference... |