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Molecular Profile | NRAS G12C |
Therapy | Panitumumab + Sotorasib |
Indication/Tumor Type | rectum cancer |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
NRAS G12C | rectum cancer | predicted - sensitive | Panitumumab + Sotorasib | Case Reports/Case Series | Actionable | In a clinical case study, the combination of Lumakras (sotorasib) and Vectibix (panitumumab) resulted in a partial response after 12 weeks in a patient with metastatic rectal cancer harboring NRAS G12C (PMID: 37262393). | 37262393 |
PubMed Id | Reference Title | Details |
---|---|---|
(37262393) | Response to (K)RASG12C and EGFR Inhibition in a Patient With NRASG12C-Mutated Rectal Cancer. | Full reference... |