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Ref Type Journal Article
PMID (37262393)
Authors Möhrmann L, Cuberi A, Brückmann S, Stasik S, Heukamp LC, Bornhäuser M, Glimm H, Folprecht G
Title Response to (K)RASG12C and EGFR Inhibition in a Patient With NRASG12C-Mutated Rectal Cancer.
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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NRAS G12C rectum cancer predicted - sensitive Panitumumab + Sotorasib Case Reports/Case Series Actionable In a clinical case study, the combination of Lumakras (sotorasib) and Vectibix (panitumumab) resulted in a partial response after 12 weeks in a patient with metastatic rectal cancer harboring NRAS G12C (PMID: 37262393). 37262393