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Molecular Profile | DNMT3A loss |
Therapy | Olaparib |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
DNMT3A loss | acute myeloid leukemia | resistant | Olaparib | Preclinical - Cell culture | Actionable | In a preclinical study, mouse acute myeloid leukemia cells harboring DNMT3A loss along with various oncogenic tyrosine kinase mutations were resistant to Lynparza (olaparib) in culture (PMID: 34215619). | 34215619 |
PubMed Id | Reference Title | Details |
---|---|---|
(34215619) | TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors. | Full reference... |