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| Molecular Profile | ALK D1225N |
| Therapy | Crizotinib |
| Indication/Tumor Type | lung adenocarcinoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ALK D1225N | lung adenocarcinoma | predicted - sensitive | Crizotinib | Case Reports/Case Series | Actionable | In a clinical case study, Xalkori (crizotinib) treatment resulted in a partial response in a patient with metastatic lung adenocarcinoma harboring ALK D1225N (PMID: 37529699). | 37529699 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (37529699) | Case report: ALK D1225N missense mutation in lung adenocarcinoma responds to tyrosine kinase inhibitors. | Full reference... |