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| Molecular Profile | APC inact mut |
| Therapy | XAV939 |
| Indication/Tumor Type | colorectal cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| APC inact mut | colorectal cancer | sensitive | XAV939 | Preclinical | Actionable | In a preclinical study, XAV939 inhibited growth of colorectal cancer cells harboring APC inactivating mutations in culture (PMID: 19759537). | 19759537 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (19759537) | Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. | Full reference... |