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Molecular Profile | APC inact mut |
Therapy | FH535 |
Indication/Tumor Type | colon carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
APC inact mut | colon carcinoma | sensitive | FH535 | Preclinical | Actionable | In a preclinical study, FH535 inhibited beta-catenin/TCF-dependent transactivation and demonstrated toxicity in colon carcinoma cells harboring an APC mutation in culture (PMID: 18347139). | 18347139 |
PubMed Id | Reference Title | Details |
---|---|---|
(18347139) | A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities. | Full reference... |