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| Molecular Profile | CTNNB1 S37F CTNNB1 S45Y |
| Therapy | WNTinib |
| Indication/Tumor Type | hepatocellular carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| CTNNB1 S37F CTNNB1 S45Y | hepatocellular carcinoma | sensitive | WNTinib | Preclinical - Patient cell culture | Actionable | In a preclinical study, WNTinib inhibited Ezh2 phosphorylation and viability in a patient-derived hepatocellular carcinoma cell line harboring CTNNB1 S37F and S45Y in culture (PMID: 37537299). | 37537299 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (37537299) | WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma. | Full reference... |