Therapy Detail

Request Content

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Therapy Name	WNTinib
Synonyms
Therapy Description	WNTinib is a multi-kinase inhibitor with activity against KIT, PDGFRA/B, VEGFR1/2, RET, and FLT3, which potentially decreases tumor growth and has selectivity for CTNNB1-mutant tumors (PMID: 37537299).

Filtering

Case insensitive filtering will display rows if any text in any cell matches the filter term
Use simple literal full or partial string matches
Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
Click on any column header arrows to sort by that column
Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Filter rows:

Showing 1 to 1 of 1 entries

Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
WNTinib			FLT3 Inhibitor 69 KIT Inhibitor 57 PDGFR Inhibitor (Pan) 30 RET Inhibitor 53 VEGFR1 Inhibitor 6 VEGFR2 Inhibitor 37	WNTinib is a multi-kinase inhibitor with activity against KIT, PDGFRA/B, VEGFR1/2, RET, and FLT3, which potentially decreases tumor growth and has selectivity for CTNNB1-mutant tumors (PMID: 37537299).

Showing 1 to 1 of 1 entries

Filter rows:

Filtering

Case insensitive filtering will display rows if any text in any cell matches the filter term
Use simple literal full or partial string matches
Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
Click on any column header arrows to sort by that column
Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Filter rows:

Showing 1 to 12 of 12 entries

Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
CTNNB1 S33F	hepatocellular carcinoma	sensitive	WNTinib	Preclinical - Patient cell culture	Actionable	In a preclinical study, WNTinib inhibited Ezh2 phosphorylation and viability in a patient-derived hepatocellular carcinoma cell line harboring CTNNB1 S33F in 2D and 3D culture (PMID: 37537299).	37537299
CTNNB1 S37F CTNNB1 S45Y	hepatocellular carcinoma	sensitive	WNTinib	Preclinical - Patient cell culture	Actionable	In a preclinical study, WNTinib inhibited Ezh2 phosphorylation and viability in a patient-derived hepatocellular carcinoma cell line harboring CTNNB1 S37F and S45Y in culture (PMID: 37537299).	37537299
CTNNB1 S45F	hepatocellular carcinoma	sensitive	WNTinib	Preclinical - Patient cell culture	Actionable	In a preclinical study, WNTinib inhibited Ezh2 phosphorylation and viability in a patient-derived hepatocellular carcinoma cell line harboring CTNNB1 S45F in culture (PMID: 37537299).	37537299
CTNNB1 S45P	hepatocellular carcinoma	sensitive	WNTinib	Preclinical - Patient cell culture	Actionable	In a preclinical study, WNTinib inhibited Ezh2 phosphorylation and viability in patient-derived hepatocellular carcinoma cell lines harboring CTNNB1 S45P in culture (PMID: 37537299).	37537299
CTNNB1 T41A	hepatocellular carcinoma	sensitive	WNTinib	Preclinical - Patient cell culture	Actionable	In a preclinical study, WNTinib inhibited Ezh2 phosphorylation and viability in patient-derived hepatocellular carcinoma cell lines harboring CTNNB1 T41A in culture (PMID: 37537299).	37537299
BRAF T529N CTNNB1 mut	hepatocellular carcinoma	predicted - sensitive	WNTinib	Preclinical - Cell culture	Actionable	In a preclinical study, WNTinib inhibited viability in a hepatocellular carcinoma cell line harboring a deletion of CTNNB1 exons and expressing BRAF T529N in culture (PMID: 37537299).	37537299
CTNNB1 G34V	hepatocellular carcinoma	sensitive	WNTinib	Preclinical - Cell culture	Actionable	In a preclinical study, WNTinib inhibited Ezh2 phosphorylation and viability in a hepatocellular carcinoma cell line harboring CTNNB1 G34V in culture (PMID: 37537299).	37537299
CTNNB1 mut KIT V559D KIT T670I	hepatocellular carcinoma	predicted - sensitive	WNTinib	Preclinical - Cell culture	Actionable	In a preclinical study, a hepatocellular carcinoma cell line harboring a deletion of CTNNB1 exons and expressing KIT V559D and T670I was resistant to WNTinib in culture (PMID: 37537299).	37537299
CTNNB1 mut MAP2K1 S218D MAP2K1 S222D	hepatocellular carcinoma	predicted - resistant	WNTinib	Preclinical - Cell culture	Actionable	In a preclinical study, a hepatocellular carcinoma cell line harboring a deletion of CTNNB1 exons and expressing MAP2K1 S218D and S222D was resistant to WNTinib in culture (PMID: 37537299).	37537299
CTNNB1 mutant	hepatocellular carcinoma	predicted - sensitive	WNTinib	Preclinical - Cell culture	Actionable	In a preclinical study, WNTinib inhibited Ezh2 phosphorylation and viability in a hepatocellular carcinoma cell line harboring a deletion of CTNNB1 exons in culture (PMID: 37537299).	37537299
CTNNB1 S37C	hepatocellular carcinoma	sensitive	WNTinib	Preclinical - Cell culture	Actionable	In a preclinical study, WNTinib inhibited Ezh2 phosphorylation and viability in a hepatocellular carcinoma cell line harboring CTNNB1 S37C in culture (PMID: 37537299).	37537299
CTNNB1 act mut	hepatocellular carcinoma	sensitive	WNTinib	Preclinical	Actionable	In a preclinical study, WNTinib increased survival in a mouse model of CTNNB1-driven hepatocellular carcinoma (PMID: 37537299).	37537299

Showing 1 to 12 of 12 entries

Filter rows:

Filtering

Case insensitive filtering will display rows if any text in any cell matches the filter term
Use simple literal full or partial string matches
Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
Click on any column header arrows to sort by that column
Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Filter rows:

Showing 0 to 0 of 0 entries

Showing 0 to 0 of 0 entries

Filter rows:

Additional content available in CKB BOOST