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Molecular Profile CTNNB1 mut KIT V559D KIT T670I
Therapy WNTinib
Indication/Tumor Type hepatocellular carcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CTNNB1 mut KIT V559D KIT T670I hepatocellular carcinoma predicted - sensitive WNTinib Preclinical - Cell culture Actionable In a preclinical study, a hepatocellular carcinoma cell line harboring a deletion of CTNNB1 exons and expressing KIT V559D and T670I was resistant to WNTinib in culture (PMID: 37537299). 37537299
PubMed Id Reference Title Details
(37537299) WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma. Full reference...