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Molecular Profile | CTNNB1 mut KIT V559D KIT T670I |
Therapy | WNTinib |
Indication/Tumor Type | hepatocellular carcinoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
CTNNB1 mut KIT V559D KIT T670I | hepatocellular carcinoma | predicted - sensitive | WNTinib | Preclinical - Cell culture | Actionable | In a preclinical study, a hepatocellular carcinoma cell line harboring a deletion of CTNNB1 exons and expressing KIT V559D and T670I was resistant to WNTinib in culture (PMID: 37537299). | 37537299 |
PubMed Id | Reference Title | Details |
---|---|---|
(37537299) | WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma. | Full reference... |