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| Molecular Profile | PALB2 del exon11 |
| Therapy | Olaparib |
| Indication/Tumor Type | endometrial serous adenocarcinoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PALB2 del exon11 | endometrial serous adenocarcinoma | predicted - sensitive | Olaparib | Case Reports/Case Series | Actionable | In a clinical case study, Lynparza (olaparib) treatment resulted in a durable response lasting 23 months in a patient with recurrent serous endometrial carcinoma harboring a germline deletion of PALB2 exon 11 (PMID: 34781271). | 34781271 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (34781271) | Germline PALB2 Variants and PARP Inhibitors in Endometrial Cancer. | Full reference... |