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| Molecular Profile | BTK L528S |
| Therapy | Fenebrutinib |
| Indication/Tumor Type | mantle cell lymphoma |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BTK L528S | mantle cell lymphoma | resistant | Fenebrutinib | Preclinical - Cell culture | Actionable | In a preclinical study, a mantle cell lymphoma cell line developed resistance to Fenebrutinib (GDC-0853) after prolonged exposure in culture, and was subsequently found to have acquired BTK L528S (PMID: 36661329). | 36661329 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (36661329) | Acquired BTK mutations associated with resistance to noncovalent BTK inhibitors. | Full reference... |