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Molecular Profile FGFR3 G384D FGFR3 over exp
Therapy Fexagratinib
Indication/Tumor Type multiple myeloma
Response Type decreased response

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR3 G384D FGFR3 over exp multiple myeloma decreased response Fexagratinib Preclinical Actionable In a preclinical study, multiple myeloma cells over expressing FGFR3 G384D had reduced sensitivity to AZD4547 in culture, compared to cells with ligand-independent activation of FGFR3 (PMID: 22869148). 22869148
PubMed Id Reference Title Details
(22869148) Tumour cell responses to new fibroblast growth factor receptor tyrosine kinase inhibitors and identification of a gatekeeper mutation in FGFR3 as a mechanism of acquired resistance. Full reference...