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Molecular Profile | BRAF V600X |
Therapy | Cetuximab + Vemurafenib |
Indication/Tumor Type | colorectal cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600X | colorectal cancer | sensitive | Cetuximab + Vemurafenib | Phase II | Actionable | In a Phase II trial, treatment with the combination of Zelboraf (vemurafenib) and Erbitux (cetuximab) resulted in an overall response rate of 4% (1/26), stable disease in 69% (18/26), and a median progression-free survival of 3.7 months in patients with BRAF V600-mutant colorectal cancer (PMID: 26287849; NCT01524978). | 26287849 |
PubMed Id | Reference Title | Details |
---|---|---|
(26287849) | Vemurafenib in Multiple Nonmelanoma Cancers with BRAF V600 Mutations. | Full reference... |