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Molecular Profile EML4 - ALK
Therapy Crizotinib
Indication/Tumor Type medullary thyroid carcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
EML4 - ALK medullary thyroid carcinoma predicted - sensitive Crizotinib Case Reports/Case Series Actionable In a clinical case study, Xalkori (crizotinib) treatment resulted in a decrease in the lung, liver, and bone lesions in a patient with metastatic medullary thyroid carcinoma harboring EML4-ALK (e13:e20) that was treated on a Phase I clinical trial (PMID: 26295973; NCT01121588). 26295973
PubMed Id Reference Title Details
(26295973) Identification of Driving ALK Fusion Genes and Genomic Landscape of Medullary Thyroid Cancer. Full reference...