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| Molecular Profile | EML4 - ALK |
| Therapy | Crizotinib |
| Indication/Tumor Type | medullary thyroid carcinoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| EML4 - ALK | medullary thyroid carcinoma | predicted - sensitive | Crizotinib | Case Reports/Case Series | Actionable | In a clinical case study, Xalkori (crizotinib) treatment resulted in a decrease in the lung, liver, and bone lesions in a patient with metastatic medullary thyroid carcinoma harboring EML4-ALK (e13:e20) that was treated on a Phase I clinical trial (PMID: 26295973; NCT01121588). | 26295973 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26295973) | Identification of Driving ALK Fusion Genes and Genomic Landscape of Medullary Thyroid Cancer. | Full reference... |