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| Molecular Profile | TP53 del |
| Therapy | M8891 |
| Indication/Tumor Type | lung cancer |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 del | lung cancer | resistant | M8891 | Preclinical - Cell culture | Actionable | In a preclinical study, knockout of TP53 conferred resistance to M8891 in a lung cancer cell line as demonstrated by loss of inhibition of colony formation in culture (PMID: 37940144). | 37940144 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (37940144) | Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models. | Full reference... |