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Therapy Name M8891
Synonyms
Therapy Description

M8891 is an inhibitor of methionine aminopeptidase 2 (MetAP2), which results in cleavage of the aminoterminal methionine residue from an early forming protein, thereby disrupting protein synthesis and potentially result in reduced proliferation of endothelial cells (PMID: 31725285).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
M8891 CS-0109402 M8891 is an inhibitor of methionine aminopeptidase 2 (MetAP2), which results in cleavage of the aminoterminal methionine residue from an early forming protein, thereby disrupting protein synthesis and potentially result in reduced proliferation of endothelial cells (PMID: 31725285).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 del lung cancer resistant M8891 Preclinical - Cell culture Actionable In a preclinical study, knockout of TP53 conferred resistance to M8891 in a lung cancer cell line as demonstrated by loss of inhibition of colony formation in culture (PMID: 37940144). 37940144

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03138538 Phase I M8891 M8891 First in Human in Solid Tumors Terminated USA 0


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