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Molecular Profile | SMARCB1 loss |
Therapy | Barasertib |
Indication/Tumor Type | epithelioid sarcoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
SMARCB1 loss | epithelioid sarcoma | sensitive | Barasertib | Preclinical - Cell culture | Actionable | In a preclinical study, Barasertib (AZD1152) inhibited viability of SMARCB1-deficient epithelioid sarcoma cell lines in culture (PMID: 38315003). | 38315003 |
PubMed Id | Reference Title | Details |
---|---|---|
(38315003) | Overcoming clinical resistance to EZH2 inhibition using rational epigenetic combination therapy. | Full reference... |