Therapy Detail
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| Therapy Name | Barasertib |
| Synonyms | |
| Therapy Description |
Barasertib (AZD1152) is a selective Aurora B kinase inhibitor, which induces cell cycle arrest (PMID: 17495131, PMID: 30540594). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Barasertib | AZD1152|AZD-1152 | Aurkb Inhibitors 21 | Barasertib (AZD1152) is a selective Aurora B kinase inhibitor, which induces cell cycle arrest (PMID: 17495131, PMID: 30540594). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| SMARCB1 loss | epithelioid sarcoma | sensitive | Barasertib | Preclinical - Cell culture | Actionable | In a preclinical study, Barasertib (AZD1152) inhibited viability of SMARCB1-deficient epithelioid sarcoma cell lines in culture (PMID: 38315003). | 38315003 |
| RB1 del SMARCB1 loss | rhabdoid cancer | sensitive | Barasertib | Preclinical - Cell culture | Actionable | In a preclinical study, Barasertib (AZD1152) inhibited viability of a SMARCB1-deficient rhabdoid cancer cell line with a deletion of RB1 in culture (PMID: 38315003). | 38315003 |
| SMARCB1 loss | rhabdoid cancer | sensitive | Barasertib | Preclinical - Cell culture | Actionable | In a preclinical study, Barasertib (AZD1152) inhibited viability of SMARCB1-deficient rhabdoid cancer cell lines in culture (PMID: 38315003). | 38315003 |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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