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Molecular Profile | ATM S214Ffs*40 ATM loss |
Therapy | ART0380 |
Indication/Tumor Type | colorectal cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ATM S214Ffs*40 ATM loss | colorectal cancer | sensitive | ART0380 | Preclinical - Pdx | Actionable | In a preclinical study, ART0380 inhibited tumor growth in a colorectal cancer patient-derived xenograft (PDX) model harboring ATM S214Ffs*40 with loss of Atm expression (PMID: 38416404). | 38416404 |
PubMed Id | Reference Title | Details |
---|---|---|
(38416404) | Ataxia-Telangiectasia Mutated (ATM) loss of function displays variant and tissue-specific differences across tumor types. | Full reference... |