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Therapy Name ART0380
Synonyms
Therapy Description

ART0380 inhibits ATR activity leading to decreased phopshorylation of Chk1, which may result in impaired DNA damage repair, induction of apoptosis in tumor cells, and antitumor activity (NCI Drug Dictionary, (Ann Oncol 34 (2023): S475-S476).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ART0380 ART-0380|ART 0380 ATR Inhibitor 16 ART0380 inhibits ATR activity leading to decreased phopshorylation of Chk1, which may result in impaired DNA damage repair, induction of apoptosis in tumor cells, and antitumor activity (NCI Drug Dictionary, (Ann Oncol 34 (2023): S475-S476).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM S214Ffs*40 ATM loss colorectal cancer sensitive ART0380 Preclinical - Pdx Actionable In a preclinical study, ART0380 inhibited tumor growth in a colorectal cancer patient-derived xenograft (PDX) model harboring ATM S214Ffs*40 with loss of Atm expression (PMID: 38416404). 38416404
ATM dec exp ATM inact mut mantle cell lymphoma predicted - sensitive ART0380 Preclinical - Cell line xenograft Actionable In a preclinical study, ART0380 inhibited cell growth of a mantle cell lymphoma cell line with an inactivating ATM mutation and decreased Atm expression in culture and inhibited tumor growth in a cell line xenograft model (PMID: 38416404). 38416404
ATM E473* ATM loss lung adenocarcinoma sensitive ART0380 Preclinical - Pdx Actionable In a preclinical study, ART0380 induced tumor regression in a lung adenocarcinoma patient-derived xenograft (PDX) model harboring ATM E473* with loss of Atm expression (PMID: 38416404). 38416404
ATM S214Pfs*16 colorectal cancer sensitive ART0380 Preclinical - Pdx Actionable In a preclinical study, ART0380 inhibited tumor growth in a colorectal cancer patient-derived xenograft (PDX) model harboring ATM S214Pfs*16 (PMID: 38416404). 38416404
ATM M779I colorectal cancer sensitive ART0380 Preclinical - Pdx Actionable In a preclinical study, ART0380 inhibited tumor growth in a colorectal cancer patient-derived xenograft (PDX) model harboring ATM M779I (PMID: 38416404). 38416404

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04657068 Phase Ib/II ART0380 + Gemcitabine ART0380 Gemcitabine A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors Recruiting USA | GBR | FRA | ESP 0
NCT05798611 Phase II ART0380 Study of ART0380 in Advanced/Metastatic Solid Tumors Patients (ARTIST) Active, not recruiting USA | FRA | ESP 0


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