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| Molecular Profile | NTRK1 G613V |
| Therapy | Selitrectinib |
| Indication/Tumor Type | dedifferentiated liposarcoma |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| NTRK1 G613V | dedifferentiated liposarcoma | resistant | Selitrectinib | Preclinical - Cell culture | Actionable | In a preclinical study, a dedifferentiated liposarcoma cell line expressing NTRK1 G613V demonstrated resistance to Selitrectinib (LOXO-195) in culture (PMID: 38531265). | 38531265 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (38531265) | A recurrent NTRK1 tyrosine kinase domain mutation pair is characteristic in a subset of dedifferentiated liposarcomas. | Full reference... |