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| Molecular Profile | FGFR3 Y375C |
| Therapy | Cediranib |
| Indication/Tumor Type | urinary bladder cancer |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FGFR3 Y375C | urinary bladder cancer | resistant | Cediranib | Preclinical | Actionable | In a preclinical study, bladder cancer cells harboring an FGFR3 Y375C mutation were resistant to growth inhibition by Cediranib (AZD-2171) in culture (PMID: 22238366). | 22238366 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (22238366) | Ponatinib (AP24534), a multitargeted pan-FGFR inhibitor with activity in multiple FGFR-amplified or mutated cancer models. | Full reference... |