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Molecular Profile KIT exon 11 del KIT V654A KIT D816A
Therapy Ripretinib + Sunitinib
Indication/Tumor Type gastrointestinal stromal tumor
Response Type resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT exon 11 del KIT V654A KIT D816A gastrointestinal stromal tumor resistant Ripretinib + Sunitinib Preclinical - Cell culture Actionable In a preclinical study, a gastrointestinal stromal tumor cell line harboring a KIT exon 11 deletion and expressing KIT V654A and D816A demonstrated resistance to the combination of Qinlock (ripretinib) and Sutent (sunitinib) in culture (PMID: 38408285). 38408285
PubMed Id Reference Title Details
(38408285) KIT ATP-Binding Pocket/Activation Loop Mutations in GI Stromal Tumor: Emerging Mechanisms of Kinase Inhibitor Escape. Full reference...