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Molecular Profile | KIT exon 11 del KIT V654A KIT D820A |
Therapy | Ripretinib + Sunitinib |
Indication/Tumor Type | gastrointestinal stromal tumor |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT exon 11 del KIT V654A KIT D820A | gastrointestinal stromal tumor | resistant | Ripretinib + Sunitinib | Preclinical - Cell culture | Actionable | In a preclinical study, a gastrointestinal stromal tumor cell line harboring a KIT exon 11 deletion and expressing KIT V654A and D820A demonstrated resistance to the combination of Qinlock (ripretinib) and Sutent (sunitinib) in culture (PMID: 38408285). | 38408285 |
PubMed Id | Reference Title | Details |
---|---|---|
(38408285) | KIT ATP-Binding Pocket/Activation Loop Mutations in GI Stromal Tumor: Emerging Mechanisms of Kinase Inhibitor Escape. | Full reference... |