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Molecular Profile RET M918T
Therapy Selpercatinib
Indication/Tumor Type thyroid gland carcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET M918T thyroid gland carcinoma predicted - sensitive Selpercatinib Case Reports/Case Series Actionable In a clinical case study, Retevmo (selpercatinib) treatment resulted in a partial response after 9 weeks of treatment, with a decrease in the size of the cervical and mediastinal lymph nodes, in a patient with metastatic recurrent mixed medullary and follicular cell-derived thyroid carcinoma harboring RET M918T, and response was maintained at 33 weeks post-treatment initiation (PMID: 38647958). 38647958
PubMed Id Reference Title Details
(38647958) Selpercatinib for treating recurrent mixed medullary and follicular cell-derived thyroid carcinoma: a case report. Full reference...